In this episode, my guest is Nolan Williams, M.D., a triple board-certified psychiatrist, neurologist and professor of psychiatry and behavioral sciences at Stanford School of Medicine. He is also the Director of the Stanford Brain Stimulation Lab. We discuss clinical applications for brain stimulation, behavioral protocols and novel drug treatments to halt and reverse mental health disorders, including depression and post-traumatic stress disorder (PTSD). We first discuss the neural circuits for self-identity and mood and stress control. We discuss Dr. Williams’ work using transcranial magnetic stimulation (TMS) to depression, trauma, PTSD, and other mood disorders. We then dive deep into the history, biology, modern use, and safety margins of the various psychedelics, including MDMA, LSD, ketamine, ibogaine, ayahuasca, and psilocybin, as well as cannabis and the use of SSRIs in both adults and children. Finally, we discuss behavioral treatments for mental health disorders, including sleep and sleep deprivation, light exposure, exercise, and training to control the brain-heart-rate pathways. Regardless of age, all those interested in mental health should benefit from the incredible breadth and depth of Dr. Williams’ knowledge and the clarity with which he conveys that information. #HubermanLab #Science Thank you to our sponsors AG1 (Athletic Greens): 🤍athleticgreens.com/huberman InsideTracker: 🤍🤍insidetracker.com/huberman Eight Sleep: 🤍🤍eightsleep.com/huberman ROKA: 🤍🤍roka.com/huberman Supplements from Momentous 🤍🤍livemomentous.com/huberman Huberman Lab Premium 🤍hubermanlab.com/premium Social & Website Instagram: 🤍🤍instagram.com/hubermanlab Twitter: 🤍twitter.com/hubermanlab Facebook: 🤍🤍facebook.com/hubermanlab TikTok: 🤍🤍tiktok.com/🤍hubermanlab LinkedIn: 🤍🤍linkedin.com/in/andrew-huberman Website: 🤍hubermanlab.com Newsletter: 🤍hubermanlab.com/neural-network Dr. Nolan Williams Stanford Profile: 🤍profiles.stanford.edu/nolan-williams Brain Stimulation Lab: 🤍bsl.stanford.edu Publications: 🤍scholar.google.com/citations?user=i4WyrcYAAAAJ&hl=en Twitter: 🤍twitter.com/nolanrywilliams LinkedIn: 🤍🤍linkedin.com/in/nolan-williams-0802a324 Articles Adjunctive triple chronotherapy (combined total sleep deprivation, sleep phase advance, and bright light therapy) rapidly improves mood and suicidality in suicidal depressed inpatients: An open label pilot study: 🤍bit.ly/3CJCWiv Development of a rational scale to assess the harm of drugs of potential misuse: 🤍bit.ly/3fJPjSI Books Breaking Open the Head: 🤍amzn.to/3fVqbIG Other Resources Brain Stimulation Lab – Ongoing & Upcoming Studies: 🤍bsl.stanford.edu/clinical-trials Magnus Medical: 🤍🤍magnusmed.com Timestamps 00:00:00 Dr. Nolan Williams, Brain Stimulation & Depression Treatment 00:03:31 Huberman Lab Premium 00:04:42 InsideTracker, Eight Sleep, ROKA 00:08:37 Momentous Supplements 00:09:16 Depression, Risk Factors, Emergency Psychiatric Treatments 00:15:11 The Brain-Heart Connection, Vagus Nerve, Prefrontal Cortex 00:17:51 Right vs. Left Brain Hemispheres & Mood Balance, Connectome 00:22:34 Heart Rate & Depression, Behavioral Interventions, Transcranial Magnetic Stimulation (TMS) 00:33:02 Prefrontal Cortex & Cognitive Control, TMS 00:37:46 AG1 (Athletic Greens) 00:39:00 Belief/Identity “Rules”, Re-scripting, TMS & Talk Therapy 00:45:49 Dorsolateral Prefrontal Cortex, TMS & Depression Treatment 00:48:36 Cingulate Cortex & Emotion, Dissociation & Catatonia 00:54:27 Ketamine, the Opioid System & Depression; Psychedelic Experience or Biology? 01:03:42 SSRIs, Serotonin & Depression; Childhood, Chemical Imbalance or Circuit? 01:13:58 Memories & “Rule” Creation; Psilocybin & “Rule” Resolution 01:21:00 MDMA & Post-Traumatic Stress Disorder (PTSD) Treatment, Psilocybin & Depression Treatment 01:24:12 Is MDMA Neurotoxic?, Drug Purity, Dopamine Surges, Post-MDMA Prolactin 01:30:38 Psilocybin, Brain Connectivity & Depression Treatment 01:34:53 Exposure Response Prevention: “Letting Go” & Depression Treatment 01:41:23 Normal Spectrums for Mental Health Disorders 01:45:35 Ibogaine & “Life Review”; PTSD, Depression & Clinical Trials 01:57:16 Clinical Use of Psychedelics 02:01:59 Ayahuasca, Brazilian Prisoner Study 02:06:55 Cannabis: THC, CBD & Psychosis, Clinical Uses 02:14:52 Personal Relative Drug Risk & Alcohol 02:20:42 Circadian Reset for Depression, Sleep Deprivation, Light 02:28:43 Stanford Neuromodulation Therapy (SNT) Study 02:34:25 Space Learning Theory & TMS Stimulation 02:45:35 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Huberman Lab Premium, Neural Network Newsletter, Social Media Disclaimer: 🤍hubermanlab.com/disclaimer Title Card Photo Credit: Mike Blabac - 🤍🤍blabacphoto.com
Thank you for providing the juice for free! This is so well structured and packed with info, marvelous ! <3
Brilliant discussion! I really loved the see-saw hinge and Stroop test analogies. I love the podcast. You do great work. Thank you!
I truly enjoyed this. Marcus and Amber are doing great things.
This exchange has altered my psychological profile, everyone who aims towards overcoming PTSD and Depression should hear this talk.
does andrew have a new black shirt every episode. because they look so fresh. that damn crisp collar.
Thank you !!!
SSRIs do not ''give people seratonin". that's nonsense.
3 minutes in and the bredth and depth of brown-nosing is trully awe-inspiring :).
I am interested in the eight sleep, and I am avoiding EMF and dirty electricity in my room at night, wonder if that is safe.
but alcohol has been here years and years before smoking cigarettes. alcohol is going nowhere.
Very informative episode. Thanks for all you and your guests do to make us a little smarter.
I wonder if you know of any research targeted to those with acquired brain Injury. It seems that the the ability of psilocybin and other compounds to promote neurogenesis and neuroplasticity could help those suffering severe traumatic brain injury or stroke. Do you know if any research targeted to these populations using psychedelics?
Thanks again for the great work!
amaze me how many talk about good things about microdosing/psychedelics.. Everyone focused on how magical psychede|ics has change their lives..I haven't tried them yet but on my “must do” list;)
I have suffered sever depression the last 4 years after my hart attack witch might have been compounded by the Staten drugs I was prescribed. As well as some family drama right now and am holding on the best I can . I found this video and it comforted me a bit. the problem is here in Saskatoon S.K. all the Doctors are leaving for Ontario and there is a two year waiting time to see a psychiatrist . I need help and it feels out of reach.
love what has been sed, only to make it supervised bij clinics is not the right thing to do... there are culteres who know how to work with there substances fore ages and called shamans. They know perfecty how to work wit these other states of consiousness.
We should start honering other culteres more and see what we can learn from them, instead of thinking we know it all bether. Sciense will always be walking one step slower then people that know how to feel..
Dynorphin an opioid peptide has a significant impact on emotional instinct & behaviour..
Lol of course he'd say that people shouldn't use them recreationally 🤣, classic Medicine.
And the clear propaganda against alcohol and weed. Disappointed in the doctor here. The bias comes through pretty hard. Let's totally forget what prohibition did lmao when will yall stop trying to "ban" shit.
It's preposterous to conclude that a substance must be prescribed simply due to the fact that it has a strong effect meanwhile being nearly physiologically harmless in comparison to hundreds of OTC meds a child can purchase. Also, it's careless at best say (N,N Dmt) (5MEO- Dmt) are basically the same thing whit a difference of duration! This is obvious neglect to tell the truth that those are completely different drugs with different effects
Can a person with Bipolar 2 benefit, and be part of the study? Would the thinking be that meds would still be required or could there be hope that this wiring reset could be enough to manage symptoms? Thank you for any info. I appreciate and learn so much from your videos - you do an excellent job of explaining, asking great questions, and choosing interesting topics. Thank you.
This discussion is fascinating!