My guest is David Anderson, PhD, a world expert in the science of sexual behavior, violent aggression, fear and other motivated states. Dr. Anderson is a Professor of Biology at the California Institute of Technology (Caltech), a member of the National Academy of Sciences and an investigator with the Howard Hughes Medical Institute (HHMI). We discuss how states of mind (and body) arise and persist and how they probably better explain human behavior than emotions per se. We also discuss the many kinds of arousal that create varying levels of pressure for certain behaviors to emerge. We discuss different types of violent aggression and how they are impacted by biological sex, gender, context, prior experience, and hormones, and the neural interconnectedness of fear, aggression and sexual behavior. We also discuss peptides and their role in social isolation-induced anxiety and aggression. Dr. Anderson also describes novel, potentially powerful therapeutics for mental health. This episode should interest anyone wanting to learn more about mental health, human emotions, sexual and/or violent behavior. Thank you to our sponsors AG1 (Athletic Greens): 🤍athleticgreens.com/huberman Levels: 🤍levels.link/huberman Helix Sleep: 🤍helixsleep.com/huberman LMNT: 🤍drinklmnt.com/huberman Supplements from Momentous 🤍🤍livemomentous.com/huberman Social & Website Instagram: 🤍🤍instagram.com/hubermanlab Twitter: 🤍twitter.com/hubermanlab Facebook: 🤍🤍facebook.com/hubermanlab TikTok: 🤍🤍tiktok.com/🤍hubermanlab LinkedIn: 🤍🤍linkedin.com/in/andrew-huberman Website: 🤍hubermanlab.com Newsletter: 🤍hubermanlab.com/neural-network Dr. David Anderson Dr. David Anderson: 🤍davidandersonlab.caltech.edu/davidanderson The Nature of the Beast: 🤍amzn.to/3qsrdOH Dr. David Anderson’s Lab: 🤍davidandersonlab.caltech.edu Dr. Anderson’s publications: 🤍bit.ly/3L5uGMl Articles Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits: 🤍bit.ly/3Dmyh7b Resources Mouse switching from mating behavior to aggressive behaviors upon stimulation of VMH: 🤍youtu.be/AIlp69kfqjw?t=882 VMH stimulation causes mouse to display aggressive behaviors toward an inanimate object (e.g., glove): 🤍youtu.be/AIlp69kfqjw?t=689 Picture of Periaqueductal Gray (PAG): 🤍neuroscientificallychallenged.com/posts/know-your-brain-periaqueductal-gray Timestamps 00:00:00 Dr. David Anderson, Emotions & Aggression 00:03:33 Momentous Supplements 00:04:27 Levels, Helix Sleep, LMNT 00:08:10 Emotions vs. States 00:10:36 Dimensions of States: Persistence, Intensity & Generalization 00:14:38 Arousal & Valence 00:18:11 Aggression, Optogenetics & Stimulating Aggression in Mice, VMH 00:24:42 Aggression Types: Offensive, Defensive & Predatory 00:29:20 Evolution & Development of Defensive vs. Offensive Behaviors, Fear 00:35:38 Hydraulic Pressures for States & Homeostasis 00:38:33 AG1 (Athletic Greens) 00:39:46 Hydraulic Pressure & Aggression 00:44:50 Balancing Fear & Aggression 00:48:31 Aggression & Hormones: Estrogen, Progesterone & Testosterone 00:52:33 Female Aggression, Motherhood 00:59:48 Mating & Aggressive Behaviors 01:05:10 Neurobiology of Sexual Fetishes 01:10:06 Temperature, Mating Behavior & Aggression 01:15:25 Mounting: Sexual Behavior or Dominance? 01:20:59 Females & Male-Type Mounting Behavior 01:24:40 PAG (Periaqueductal Gray) Brain Region: Pain Modulation & Fear 01:30:38 Tachykinins & Social Isolation: Anxiety, Fear & Aggression 01:43:49 Brain, Body & Emotions; Somatic Marker Hypothesis & Vagus Nerve 01:52:52 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, AG1 (Athletic Greens), Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Title Card Photo Credit: Mike Blabac - 🤍🤍blabacphoto.com
My question got answered about 20 minutes later. 😊
The mice that will mount a kumquat... Since the word “mount” is used, I am assuming we are talking about male mice. What about the female mice? How is their behavior altered? I am really hoping that in the 2020’s, we are finally looking at the behavior of both genders, not just male - mice or human.
@ uxZFl4BDOGk&t=43m00s 43:00 + will that mouse attack a dead mouse? A fake/paper mouse that’s been in there with it that it recognized previously as no threat?
Fabulous podcast.
1) I wonder if 'irrespective of the type of aggression' ; predatory or defensive --hydraulic pressure towards a specific state is influenced by 'social context' and 'genetics' irrespective of one's; 'internal or external emotional state'
2)What I find offensive or what triggers me has evolved over a period of time which maybe at odds with what is 'acceptable' at a societal level ( could this be due to revised world view - I doubt this. I also wondered if 'significant key events' in one's life change how an individual 'reacts' [performance anxiety]
Reading the book currently. Very well done blending the professional presentation of an academic/scientific document and yet made accessible to lay audiences as much as possible.
uxZFl4BDOGk&t=1h06m35s 1:06:35 bro.... You obviously haven't been dating recently. People have fetishes to alllll kinds of things. Balloons, fettuccine alfredo, bicycle shorts, bread rolls, reading glasses, red hair. And that's just off the top of my head of things myself and my friends have come across in regular dating. Ask a sex worker what they've come across and the list will likely turn into the encyclopaedia.
Ty McCracken
0 seconds ago
I'm listening to this a few months after original posting so I don't know if this question will catch your attention. I listened to the interview with Dr. Anderson first and then this one so my question is born from both podcasts. However, if you happen to find it, I am very interested in your thoughts (and greatly appreciative of your time). With the information that proactive and reactive aggression are distinct; is there any evidence...or potential hypothesis...as to whether one or the other (proactive v. reactive) is more resilient? Example - if proactive aggression is stimulated in subject A and reactive aggression in subject B, will one subject be more resilient in the expression of aggressive behaviors than the other? Or perhaps, a better term than resilient is persistent. Is one more persistent than the other?
"The total intellectual power of any of their comments is that of a cap gun"
This is the most casually devastating roast of Twitter users lmao
I think I’m in love with Dr. Andrew Huberman..
I'm just popping in to say THANK YOU for creatiing a platform to discuss, and dissect the current relevant literature on various topics!
Actually, people do sometimes develop fetishes to mailboxes and other inanimate objects - it’s called objectophilia. And Dr Jim Pfaus, a sexual neuroscientist who used to be at Concordia, has created what could be considered a type of fetishistic interest in rats toward these little jackets they’d have them wear :) You should have Pfaus on the show
This episode is insanely interesting! The complex scientific breakdowns, observations and terminology can convolute or disguise some of the more obvious truths. Living creatures Trumpet or Compete for Mating Rights. Hence the reasons the brains circuitry is so closing connected for the Five Fs. Feeding, Fighting, Fleeing, F***ing, Freezing!
W CONTENT CREATOR W NEURO SCIENTIST W GUEST
What a beautiful conversation between two incredible scientists that was!
uxZFl4BDOGk&t=01h21m20s 01:21:20 . What The Function 😂
I am Curious about the studies Dr Anderson was referring to about the Vagus Nerve mapping (for a lack of a better word)...
Any guidance 💪🏽🙌💜
spoiler, big pharma doesn't actually want to fix anything
I love you Doc…but hearing you tiptoe around facts and human nature is painful.